Preclinical evidence for employing MEK inhibition in NRAS mutated pediatric gastroenteropancreatic neuroendocrine-like tumors

Background: Pediatric gastroenteropancreatic neuroendocrine tumors are exceedingly rare, resulting in most pediatric treatment recommendations being based on Pest control data derived from adults.Trametinib is a kinase inhibitor that targets MEK1/2 and has been employed in the treatment of cancers harboring mutations in the Ras pathway.Methods: We

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Tocodynamometry in canine uterine inertia

Early detection of uterine inertia is very crucial for the life of the foetus as well as that of the dam.Suitable methods for early detection of uterine inertia are lacking in canines compared to humans.Non-invasivetocodynamometry is a promising method, which Potato Mashers is widely used in humans for the management of uterine inertia.In the prese

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